Ceramide supplementation, what are the benefits for the skin?

Aurélie SIFFRE, Doctor of Pharmacy, answers our questions.

The skin is the largest organ in the human body. Its main functions include protecting the body, regulating body temperature, maintaining water balance and synthesising vitamin D. The skin is made up of 3 different layers.

This article will take a particular interest in the ceramides present in the outermost part of the epidermis known as the stratum corneum, which acts as a barrier. [1]

What role do ceramides play in the skin?

These are sphingolipids, lipids found in cell membranes.

9 to 11 classes of ceramides have been identified in humans. They represent 40% of the lipids in the stratum corneum, and are like the cement in a brick wall. They bind the cells together, slowing down the loss of water from the body and the penetration of harmful substances from the outside, while giving the whole skin suppleness and cohesion.

A reduction in ceramides will lead to dryness, itching, flaking and cracking of the skin. The idea of enriching moisturising creams with ceramides or taking them orally has therefore rapidly gained ground in the cosmetics industry and in food supplements, in the same way as hyaluronic acid or collagen [2].

Studies suggest that ceramides act indirectly on collagenase and elastase [3]. Both are involved in the skin ageing process.

From what source are ceramides extracted?

Animal sources were quickly ruled out in the wake of the BSE crisis, and since then research has focused on synthetic ceramides and plant ceramides (wheat extracts, for example). [2]

Ceramides are naturally present in wheat grains (1-2% of their composition). They are widely used in Europe and offer the advantage of plant-based formulations.

Which combination in food supplements?

In addition to ceramides, we often see a combination of vitamin C, antioxidants, grape-seed extract and hyaluronic acid.

Complementary advice from the pharmacist

In general, to combat skin ageing, you should focus on:

• A diet rich in antioxidants
• Regular exercise
• Use sun protection
• Not smoking
• Keep well hydrated. [4]

The use of food supplements or suitable creams will reinforce the effectiveness of dietary hygiene advice.

Laboratoire PYC offers a new ceramide-based food supplement

The ADVANCED CERAMIDES formula is vegan and clean label. It is made up of SEPPIC’s clinically proven CERAMOSIDES™. It also contains grape seed extract and vitamin C.

For any food supplement development request:

[1] MSD Manual Consumer Version, Structure and function of the skin

[2] CosmeticOBS, Ceramides 

[3] Internal source, supplier of ceramides

[4] Dermato-info, Le vieillissement de la peau